Nezolid 600mg TAB (Linezolid)

Based on the description “Nezolid 600mg TAB (Linezolid)”, here’s a detailed breakdown:

### 1. **Product Name:** Nezolid
* **Brand name** for the generic drug **Linezolid**.
* Common in certain regions (e.g., India, Bangladesh).

### 2. **Active Ingredient:** Linezolid
* A **synthetic antibiotic** belonging to the **oxazolidinone class**.
* **Mechanism:** Inhibits bacterial protein synthesis by binding to the 23S ribosomal RNA of the 50S subunit. Unique mechanism means **no cross-resistance** with other antibiotic classes.

### 3. **Dosage Form:** Tablet (TAB)
* Oral solid dosage form. Usually film-coated for easier swallowing.

### 4. **Strength:** 600mg
* Standard adult therapeutic dose per tablet.
* **Typical Adult Dose:** **600 mg every 12 hours** (twice daily).

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### KEY FEATURES & USES:
* **Spectrum:** Primarily effective against **Gram-positive bacteria**, including:
* **MRSA** (Methicillin-Resistant *Staphylococcus aureus*)
* **VRE** (Vancomycin-Resistant *Enterococci* – both *E. faecalis* & *E. faecium*)
* Penicillin-resistant *Streptococcus pneumoniae*
* *Staphylococcus aureus* (including MSSA), *Streptococcus pyogenes*, *Streptococcus agalactiae*
* **Indications:** Treats serious infections caused by susceptible Gram-positive bacteria:
* Nosocomial & Community-Acquired **Pneumonia**
* Complicated & Uncomplicated **Skin and Soft Tissue Infections** (SSTIs)
* **Vancomycin-Resistant Enterococcal (VRE) Infections**
* **Bacteremia**
* **Reserve Antibiotic:** Used for **resistant infections** when other options fail or are unsuitable. *Not* a first-line drug for routine infections.

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### IMPORTANT CONSIDERATIONS & WARNINGS:
1. **Black Box Warning (US FDA):**
* **Monoamine Oxidase Inhibition (MAOI):** Linezolid is a reversible, non-selective MAO inhibitor.
* **Serotonin Syndrome:** Risk is high if taken with **SSRIs, SNRIs, TCAs, triptans, MAOIs, bupropion, buspirone, dextromethorphan**, or stimulants. Symptoms: agitation, hallucinations, fever, sweating, tremor, muscle rigidity.
* **Tyramine Interaction:** Avoid **aged cheeses, cured meats, tap beers, red wine, soy sauce**. Can cause severe hypertension.
* **Myelosuppression:** Can cause **thrombocytopenia** (low platelets), anemia, leukopenia. Risk increases with use >2 weeks. Monitor CBC weekly.

2. **Duration Limitation:**
* Generally limited to **10-14 days** (max 28 days) due to increasing risk of bone marrow suppression and irreversible peripheral/optic neuropathy with longer use.

3. **Administration:**
* Can be taken **with or without food**.
* **Swallow whole;** do not crush, split, or chew.

4. **Contraindications/Cautions:**
* Hypersensitivity to linezolid.
* Uncontrolled hypertension, pheochromocytoma, carcinoid syndrome.
* Pregnancy/Lactation: Use only if clearly needed (Category C).
* Renal/Hepatic Impairment: Dose adjustment usually *not* needed, but monitor closely.

5. **Drug Interactions:**
* **Strong CYP450 Inducers (e.g., rifampin):** May reduce linezolid efficacy.
* **Adrenergic/Sympathomimetic Agents:** Potentiated pressor response.
* **Serotonergic Agents:** Absolute contraindication (see Serotonin Syndrome above).

6. **Common Side Effects:**
* Diarrhea, nausea, vomiting, headache, taste changes.
* Lactic acidosis (rare but serious).

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### PACKAGING:
* “TAB” implies tablets, likely in blister strips.
* Common packs: 10 tablets (5-day course), 20 tablets (10-day course), or hospital unit doses.

**In Summary:**
**Nezolid 600mg TAB** is a potent oral antibiotic (Linezolid) used for serious Gram-positive infections like MRSA, VRE, pneumonia, and complex skin infections. It carries significant risks (MAOI effects, bone marrow suppression) requiring strict adherence to dosing limits (600mg twice daily, ≤14 days), avoidance of interacting drugs/foods, and regular blood monitoring. **Always use under strict medical supervision.**