VITAZON-D (CHOLECALCIFEROL) 5MG/ML(200000I.U)

Based on the description “VITAZON-D (CHOLECALCIFEROL) 5MG/ML (200000 I.U)”, here’s a comprehensive breakdown:

**1. Product Name:** VITAZON-D
* This is the brand name.
* The “-D” clearly indicates it contains Vitamin D.

**2. Active Ingredient:** Cholecalciferol
* This is **Vitamin D3**, the natural form of vitamin D produced by the skin in sunlight and found in some animal-based foods.
* Essential for calcium and phosphorus absorption, bone mineralization, muscle function, nerve signaling, and immune modulation.

**3. Dosage Form & Route:** **Injectable Solution**
* The concentration (5mg/ml) and high potency confirm it’s designed for **injection**, specifically **Intramuscular (IM)** injection into a large muscle (e.g., buttock, thigh).
* *Not* for oral use or intravenous injection (unless explicitly stated in prescribing info).

**4. Concentration:** **5 mg/ml**
* This means each **milliliter (ml)** of the solution contains **5 milligrams (mg)** of Cholecalciferol (Vitamin D3).

**5. Potency in International Units (IU):** **200,000 IU/ml**
* Vitamin D potency is commonly expressed in International Units (IU).
* The standard conversion is: **1 µg (microgram) Cholecalciferol = 40 IU**.
* Therefore:
* 1 mg (1000 µg) Cholecalciferol = 40,000 IU
* 5 mg Cholecalciferol = 5 * 40,000 IU = **200,000 IU**
* **This is an extremely high concentration per ml, confirming it is a potent prescription medication.**

**In Summary: VITAZON-D is a prescription-only, high-potency intramuscular injection of Vitamin D3 (Cholecalciferol). Each milliliter contains 5 mg (equivalent to 200,000 IU) of Vitamin D3.**

**Critical Characteristics & Considerations:**

* **Prescription Medication:** This is **not** an over-the-counter supplement. It requires a doctor’s prescription and supervision.
* **Purpose:** Used to rapidly correct **severe vitamin D deficiency** or manage conditions requiring high-dose therapy when oral intake is ineffective, impractical, or contraindicated (e.g., malabsorption syndromes like Crohn’s, celiac, post-bariatric surgery; patients unable to take oral meds).
* **High Dose & Toxicity Risk:** The high concentration (200,000 IU/ml) poses a significant risk of **Vitamin D toxicity (Hypervitaminosis D)** if dosed incorrectly. This can lead to dangerous **hypercalcemia** (high blood calcium), causing kidney damage, bone pain, nausea, vomiting, confusion, and heart rhythm problems.
* **Dosing:** Dosing is **highly individualized** based on:
* Severity of deficiency (confirmed by blood test – Serum 25-OH-D)
* Patient’s weight and underlying health conditions
* Treatment goals
* Doses can be large single “loading” doses (e.g., 300,000 – 600,000 IU) or smaller repeated doses. **Self-administration is absolutely not appropriate.**
* **Essential Monitoring:** Requires **strict medical supervision** with regular blood tests:
* **Serum 25-Hydroxyvitamin D:** To monitor treatment response and avoid toxicity.
* **Serum Calcium:** To detect hypercalcemia early.
* **Contraindications:** Should not be used in patients with:
* Hypercalcemia (high blood calcium)
* Hypervitaminosis D (existing Vitamin D toxicity)
* Known hypersensitivity to cholecalciferol or any excipients in the formulation.
* **Drug Interactions:** Can interact significantly with:
* Thiazide diuretics (increased hypercalcemia risk)
* Cardiac glycosides (Digoxin – increased risk of arrhythmias)
* Other Vitamin D analogs
* Magnesium-containing antacids/laxatives
* Certain anti-seizure medications (e.g., phenytoin, phenobarbital)
* Corticosteroids (can reduce effectiveness)
* Orlistat, cholestyramine (can reduce absorption of *oral* Vitamin D, less relevant for IM)
* **Packaging:** Likely supplied in **ampoules or vials** (e.g., 1ml ampoule containing 5mg/200,000 IU).
* **Storage:** Typically requires **refrigeration (2°C – 8°C)** and protection from light. **Always check the product leaflet.**
* **Excipients:** May contain oils (like sesame or peanut oil as a solvent), preservatives, or stabilizers. Check the leaflet for allergens.
* **Sodium Content:** Some injectable formulations contain sodium; important for patients on strict sodium-restricted diets.

**Conclusion:** VITAZON-D (Cholecalciferol) 5mg/ml (200,000 IU) is a powerful injectable medication for treating severe Vitamin D deficiency under strict medical supervision. Its high potency necessitates careful dosing and monitoring to achieve therapeutic benefits while avoiding serious toxicity risks like hypercalcemia.

**Always use this medication exactly as prescribed by a doctor and refer to the official prescribing information leaflet for complete details on administration, dosing, warnings, precautions, and storage.**