BEFLAM 75MG TAB

**BEFLAM 75MG TAB (Diclofenac Potassium) Description**
**Generic Name:** Diclofenac Potassium
**Drug Class:** Nonsteroidal Anti-Inflammatory Drug (NSAID)

**Mechanism of Action:**
Inhibits cyclooxygenase (COX-1 and COX-2) enzymes, reducing prostaglandin synthesis, which mediates pain, inflammation, and fever.

**Indications:**
– Osteoarthritis, rheumatoid arthritis, ankylosing spondylitis
– Acute musculoskeletal pain (e.g., sprains, strains)
– Migraine attacks
– Primary dysmenorrhea (menstrual cramps)
– Postoperative or dental pain

**Dosage Form/Strength:**
– Immediate-release tablet, 75 mg (potassium salt for rapid absorption).

**Dosing:**
– **Adults:** 75 mg twice daily (max 150 mg/day), taken with food to minimize GI irritation.
– Duration: Short-term use recommended to reduce risks.

**Key Pharmacokinetics:**
– Rapid absorption (onset ~30 minutes) due to potassium salt formulation.
– Peak plasma concentration: ~2–3 hours.

**Common Side Effects:**
– Gastrointestinal: Nausea, dyspepsia, abdominal pain, diarrhea, ulceration.
– Cardiovascular: Elevated blood pressure, fluid retention.
– Renal: Reduced kidney function (risk in predisposed patients).
– Other: Headache, dizziness.

**Serious Risks/Warnings:**
– **GI Bleeding/Ulcers:** Higher risk with prolonged use, alcohol, or history of ulcers.
– **Cardiovascular:** Increased risk of thrombosis, MI, or stroke (avoid in CVD patients).
– **Renal Impairment:** Contraindicated in severe renal dysfunction.
– **Hypersensitivity:** Avoid in aspirin/NSAID-induced asthma or urticaria.

**Contraindications:**
– Active peptic ulcer, 3rd-trimester pregnancy, severe heart/kidney/hepatic failure.

**Drug Interactions:**
– **Anticoagulants (e.g., warfarin):** Increased bleeding risk.
– **ACE Inhibitors/Diuretics:** Reduced antihypertensive effect.
– **Other NSAIDs/Corticosteroids:** Additive GI toxicity.

**Precautions:**
– Use lowest effective dose for shortest duration.
– Monitor renal function and blood pressure in long-term use.
– Avoid alcohol.

**Brand Note:** BEFLAM is a brand formulation of diclofenac potassium; generic equivalents may exist.

*Always consult a healthcare provider for personalized dosing and safety guidance.*